Waldenstroem macroglobulinemia

IgM分泌異常症　IgM-Secreting Disorders†

LPL/WMの鑑別診断には,IgM MGUSや無症候性または,くすぶり型WMなど,血清IgMパラ蛋白serum IgM paraproteinの存在が主要な症状である疾患が含まれる.

↑

IgM MGUS†

*1  McMaster ML, Caporaso N. Waldenstrom macroglobulinaemia and IgM monoclonal gammopathy of undetermined significance: emerging understanding of a potential precursor condition. Br J Haematol 2007; 139: pp. 663-671.
*2  Varettoni M, Arcaini L, Zibellini S, et. al.: Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenstrom's macroglobulinemia and related lymphoid neoplasms. Blood 2013; 121: pp. 2522-2528.
*3  Xu L, Hunter ZR, Yang G, et. al. MYD88 L265P in Waldenstrom macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction. Blood 2013; 121: pp. 2051-2058.
*4  Xu L, Hunter ZR, Yang G, et. al. Detection of MYD88 L265P in peripheral blood of patients with Waldenstrom's Macroglobulinemia and IgM monoclonal gammopathy of undetermined significance. Leukemia 2014; 28: pp. 1698-1704.
*5  Varettoni M, Zibellini S, Arcaini L, et. al.: MYD88 (L265P) mutation is an independent risk factor for progression in patients with IgM monoclonal gammopathy of undetermined significance. Blood 2013; 122: pp. 2284-2285.
*6  Landgren O, Staudt L: MYD88 L265P somatic mutation in IgM MGUS. N Engl J Med 2012; 367: pp. 2255-2256. author reply 2256-2257
*7  Jimenez C, Sebastian E, Chillon MC, et. al.: MYD88 L265P is a marker highly characteristic of, but not restricted to, Waldenstrom's macroglobulinemia. Leukemia 2013; 27: pp. 1722-1728.
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