Haematopathology-WHO 5th classification
WHO 5th Classification of Lymphoid classification†
2022年7月時点の文献--Leukemia;
B-cell proliferation/ B-cell lymphoma†
T-cell and NK cell LPD/lymphomaを見る
Tumour-like lesions with B-cell predominance†
- Reactive B-cell-rich lymphoid proliferations that can mimic lymphoma *
- Unicentric Castleman disease*
- Idiopathic multicentric Castleman disease*
- KSHV/HHV8-associated multicentric Castleman disease ( 4th Edでは, Multicentric Castleman disease
*; Not previously included in WHO 4th Ed
Precursor B-cell neoplasms†
B-cell lymphoblastic leukaemias/lymphomas []; WHO 4th Ed
- B-lymphoblastic leukaemia/lymphoma, NOS [Same]
- B-lymphoblastic leukaemia/lymphoma with high hyperdiploidy [B-lymphoblastic leukaemia/lymphoma with hyperdiploidy]
- B-lymphoblastic leukaemia/lymphoma with hypodiploidy [Same]
- B-lymphoblastic leukaemia/lymphoma with iAMP21 [Same]
- B-lymphoblastic leukaemia/lymphoma with BCR::ABL1 fusion [B-lymphoblastic leukaemia/lymphoma with t(9;22)(q34;q11.2); BCR-ABL1]
- B-lymphoblastic leukaemia/lymphoma with BCR::ABL1-like features [B-lymphoblastic leukaemia/lymphoma, BCR-ABL1-like]
- B-lymphoblastic leukaemia/lymphoma with KMT2A rearrangement [B-lymphoblastic leukaemia/lymphoma with t(v;11q23.3); KMT2A-rearranged]
- B-lymphoblastic leukaemia/lymphoma with ETV6::RUNX1 fusion [B-lymphoblastic leukaemia/lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1]]
- B-lymphoblastic leukaemia/lymphoma with ETV6::RUNX1-like features [Not previously included]
- B-lymphoblastic leukaemia/lymphoma with TCF3::PBX1 fusion [B-lymphoblastic leukaemia/lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1]
- B-lymphoblastic leukaemia/lymphoma with IGH::IL3 fusion [B-lymphoblastic leukaemia/lymphoma with t(5;14)(q31.1;q32.1); IGH/IL3]
- B-lymphoblastic leukaemia/lymphoma with TCF3::HLF fusion [Not previously included]
- B-lymphoblastic leukaemia/lymphoma with other defined genetic abnormalities [same]
Mature B-cell neoplasms†
Pre-neoplastic and neoplastic small lymphocytic proliferations
- Monoclonal B-cell lymphocytosis (Same)
- Chronic lymphocytic leukaemia/small lymphocytic lymphoma (Same)
- [B-cell prolymphocytic leukaemia]; Entity deleted
Splenic B-cell lymphomas and leukaemias
- Hairy cell leukaemia (Same)
- Splenic marginal zone lymphoma (Same)
- Splenic diffuse red pulp small B-cell lymphoma (Same)
- Splenic B-cell lymphoma/leukaemia with prominent nucleoli [Not previously included (encompassing hairy cell leukaemia variant and some cases of B-cell prolymphocytic leukaemia)]
Lymphoplasmacytic lymphoma
- Lymphoplasmacytic lymphoma [same]
Marginal zone lymphoma
- Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue [same]
- Primary cutaneous marginal zone lymphoma [Not previously included (originally included under “extranodal marginal zone
lymphoma of mucosa-associated lymphoid tissue”)]
- Nodal marginal zone lymphoma [same]
- Paediatric marginal zone lymphoma [same]
Follicular lymphoma
- In situ follicular B-cell neoplasm In situ follicular neoplasia
- Follicular lymphoma [Same]
- Paediatric-type follicular lymphoma [Same]
- Duodenal-type follicular lymphoma [Same]
Cutaneous follicle centre lymphoma
- Primary cutaneous follicle centre lymphoma [Same]
Mantle cell lymphoma
- In situ mantle cell neoplasm In situ mantle cell neoplasia
- Mantle cell lymphoma [Same]
- Leukaemic non-nodal mantle cell lymphoma [Same]
Transformations of indolent B-cell lymphomas
- Transformations of indolent B-cell lymphomas [Not previously included]
Large B-cell lymphomas
- Diffuse large B-cell lymphoma, NOS [Same]
- T-cell/histiocyte-rich large B-cell lymphoma [Same]
- Diffuse large B-cell lymphoma/ high grade B-cell lymphoma with MYC and BCL2 rearrangements
- High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements
- ALK-positive large B-cell lymphoma [Same]
- Large B-cell lymphoma with IRF4 rearrangement [Same]
- High-grade B-cell lymphoma with 11q aberrations Burkitt-like lymphoma with 11q aberration
- Lymphomatoid granulomatosis [Same]
- EBV-positive diffuse large B-cell lymphoma EBV-positive diffuse large B-cell lymphoma, NOS
- Diffuse large B-cell lymphoma associated with chronic inflammation [Same]
- Fibrin-associated large B-cell lymphoma Not previously included [Previously considered a subtype of diffuse large B-cell lymphoma associated with chronic inflammation]
- Fluid overload-associated large B-cell lymphoma Not previously included
- Plasmablastic lymphoma [Same]
- Primary large B-cell lymphoma of immune-privileged sites Not previously included, encompassing primary diffuse large B-cell lymphoma of the CNS in revised 4th edition [plus primary large B-cell lymphoma of the vitreoretina and primary large B-cell lymphoma of the testis]
- Primary cutaneous diffuse large B-cell lymphoma, leg type [Same]
- Intravascular large B-cell lymphoma [Same]
- Primary mediastinal large B-cell lymphoma [Same]
- Mediastinal grey zone lymphoma B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classic Hodgkin lymphoma
- High-grade B-cell lymphoma, NOS [Same]
Burkitt lymphoma
KSHV/HHV8-associated B-cell lymphoid proliferations and lymphomas
- Primary effusion lymphoma [Same]
- KSHV/HHV8-positive diffuse large B-cell lymphoma HHV8-positive diffuse large B-cell lymphoma, NOS
- KSHV/HHV8-positive germinotropic lymphoproliferative disorder
- HHV8-positive germinotropic lymphoproliferative disorder
Lymphoid proliferations and lymphomas associated with immune deficiency and dysregulation
- Hyperplasias arising in immune deficiency/dysregulation [Not previously included, encompassing non-destructive post-transplant lymphoproliferative disorders, among others]
- Polymorphic lymphoproliferative disorders arising in immune deficiency/dysregulation [Not previously included, encompassing polymorphic posttransplant lymphoproliferative disorders, other iatrogenic immunodeficiency-associated lymphoproliferative disorders, among others]
- EBV-positive mucocutaneous ulcer [Same]
- Lymphomas arising in immune deficiency / dysregulation [Not previously included, encompassing monomorphic posttransplant
lymphoproliferative disorders, classic Hodgkin lymphoma posttransplant lymphoproliferative disorders, lymphomas associated with HIV infection, among others]
- Inborn error of immunity-associated lymphoid proliferations and lymphomas [Lymphoproliferative diseases associated with primary immune disorders]
Hodgkin lymphoma†
- Classic Hodgkin lymphoma [Same]
- Nodular lymphocyte predominant Hodgkin lymphoma [Same]
Plasma cell neoplasms and other diseases with paraproteins†
- Cold agglutinin disease Not previously included IgM monoclonal gammopathy of undetermined significance [Same]
- Non-IgM monoclonal gammopathy of undetermined significance [Same]
- Monoclonal gammopathy of renal significance [Not previously included]
Diseases with monoclonal immunoglobulin deposition
- Immunoglobulin-related [AL] amyloidosis [Primary amyloidosis]
- Monoclonal immunoglobulin deposition disease [Light chain and heavy chain deposition disease]
Heavy chain diseases
- Mu heavy chain disease [Same]
- Gamma heavy chain disease [Same]
- Alpha heavy chain disease [Same]
Plasma cell neoplasms
- Plasma cell myeloma [Same]
- Plasma cell neoplasms with associated paraneoplastic syndrome
T-cell and NK ell proliferation/lymphoma†
[ ]内はWHO 4th revised でのentity名です. 5th Edでは削除された項目もある. [Not previously included]は5thで新たに加えられたentity, [Same]は変更なしのentity.
Tumour-like lesions with T-cell predominance†
- Kikuchi-Fujimoto disease [Not previously included]
- Indolent T-lymphoblastic proliferation [Not previously included]
- Autoimmune lymphoproliferative syndrome [Not previously included]
Precursor T-cell neoplasms†
T-lymphoblastic leukaemia/lymphoma
- T-lymphoblastic leukaemia / lymphoma, NOS [T-lymphoblastic leukaemia/lymphoma]
- Early T-precursor lymphoblastic leukaemia / lymphoma [Early T-cell precursor lymphoblastic leukaemia]
- [Entity deleted] NK-lymphoblastic leukaemia/lymphoma
Mature T-cell and NK-cell neoplasms†
Mature T-cell and NK-cell leukaemias
- T-prolymphocytic leukaemia [Same]
- T-large granular lymphocytic leukaemia [T-cell large granular lymphocytic leukaemia]
- NK-large granular lymphocytic leukaemia [Chronic lymphoproliferative disorder of NK cells]
- Adult T-cell leukaemia/lymphoma [Same]
- Aggressive NK-cell leukaemia [Same]
Primary cutaneous T-cell lymphomas
- Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder [Same]
- Primary cutaneous acral CD8-positive lymphoproliferative disorder [Primary cutaneous acral CD8-positive T-cell lymphoma]
- Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Lymphomatoid papulosis [Same]
- Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Primary cutaneous anaplastic large cell lymphoma [Same]
- Subcutaneous panniculitis-like T-cell lymphoma [Same]
- Primary cutaneous gamma/delta T-cell lymphoma [Same]
- Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma [Same]
- Primary cutaneous peripheral T-cell lymphoma, NOS [Not previously included]
Intestinal T-cell and NK-cell lymphoid proliferations and lymphomas
- Indolent T-cell lymphoma of the gastrointestinal tract Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract
- Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract [Not previously included]
- Enteropathy-associated T-cell lymphoma [Same]
- Monomorphic epitheliotropic intestinal T-cell lymphoma [Same]
- Intestinal T-cell lymphoma, NOS [Same]
Hepatosplenic T-cell lymphoma
- Hepatosplenic T-cell lymphoma [Same]
Anaplastic large cell lymphoma
- ALK-positive anaplastic large cell lymphoma [Anaplastic large cell lymphoma, ALK-positive]
- ALK-negative anaplastic large cell lymphoma [Anaplastic large cell lymphoma, ALK-negative]
- Breast implant-associated anaplastic large cell lymphoma [Same]
Nodal T-follicular helper [TFH] cell lymphoma
- Nodal TFH cell lymphoma, angioimmunoblastic-type Angioimmunoblastic T-cell lymphoma
- Nodal TFH cell lymphoma, follicular-type Follicular T-cell lymphoma
- Nodal TFH cell lymphoma, NOS Nodal peripheral T-cell lymphoma with TFH phenotype
Other peripheral T-cell lymphomas
- Peripheral T-cell lymphoma, not otherwise specified [Same]
EBV-positive NK/T-cell lymphomas
- EBV-positive nodal T- and NK-cell lymphoma Not previously included
- Extranodal NK/T-cell lymphoma Extranodal NK/T-cell lymphoma, nasal-type
EBV-positive T- and NK-cell lymphoid proliferations and lymphomas of childhood
- Severe mosquito bite allergy [Same]
- Hydroa vacciniforme lymphoproliferative disorder [Hydroa vacciniforme-like lymphoproliferative disorder]
- Systemic chronic active EBV disease [Chronic active EBV infection of T- and NK-cell type, systemic form]
- Systemic EBV-positive T-cell lymphoma of childhood [Same]
Mesenchymal dendritic cell neoplasms†
- Follicular dendritic cell sarcoma [Same]
- EBV-positive inflammatory follicular dendritic cell sarcoma Inflammatory pseudotumour-like follicular/fibroblastic dendritic cell sarcoma
- Fibroblastic reticular cell tumour [Same]
- Intranodal palisaded myofibroblastoma [Not previously included]
Spleen-specific vascular-stromal tumours
- Splenic vascular-stromal tumours
- Littoral cell angioma [Not previously included]
- Splenic hamartoma [Not previously included]
- Sclerosing angiomatoid nodular transformation of spleen [Not previously included]
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