![[PukiWiki]](image/title-logo.png "[PukiWiki]"){kind=logo}
#author("2022-08-23T15:31:57+09:00","","") #author("2022-08-23T15:32:05+09:00","","") [[Wikipathologica-KDP]] [[Tyrosine kinase]] [[Tyrosine kinases]] *'''MET''' met proto-oncogene '''MET'''遺伝子 [#u2b139d9] '''''MET''''' 染色体17q31に位置するがん遺伝子で''HGF/SF(scatter factor 細胞分散因子)''をリガンドとする''膜型受容体チロシンキナーゼ''。 1984年に化学発がん物質により突然変異したヒト骨肉腫細胞株においてchromosome1q25に局在する'''TPR'''(translocation promoter region)遺伝子の融合遺伝子'''''TRP-MET'''''として同定された((Cooper CS, et al. Nature. 1984 Sep 6-11;311(5981):29-33. Molecular cloning of a new transforming gene from a chemically transformed human cell line. PMID: 6590967))。 MET受容体チロシンキナーゼ経路の制御異常は、細胞増殖, アポトーシス回避(細胞生存), 血管増生, 浸潤、遠隔転移に関わっている。((Rubin JS, et al. A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor.Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):415-9. PMID:1824873))((Stoker M, et al. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature. 1987 May 21-27;327(6119):239-42. PMID: 2952888))((Jeffers M, et al. Hepatocyte growth factor/scatter factor-Met signaling induces proliferation, migration, and morphogenesis of pancreatic oval cells. Cell Growth Differ. 1996 Dec;7(12):1805-13.PMID: 8959349))((Jeffers M, et al. Hepatocyte growth factor/scatter factor-Met signaling in tumorigenicity and invasion/metastasis. J Mol Med (Berl). 1996 Sep;74(9):505-13. PMID:8892055))((Grant DS, et al. Scatter factor induces blood vessel formation in vivo. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1937-41. PMID:7680481))
