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#author("2022-07-17T22:20:25+09:00","","") #author("2022-07-17T22:25:24+09:00","","") [[Haematopathology-WHO 5th classification]] *WHO 5th Classification of Lymphoid classification [#a65d4225] 2022年7月時点の文献--Leukemia; 2022年7月時点の文献--Alaggio R et al., Leukemia 2022; Jul;36(7):1720-1748. ¬e{:Alaggio R et al., Leukemia 2022; Jul;36(7):1720-1748.The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms}; *B-cell proliferation/ B-cell lymphoma [#id596110] #br [[T-cell and NK cell LPD/lymphomaを見る>#T-cell]] ***Tumour-like lesions with B-cell predominance [#o6e4b291] -Reactive B-cell-rich lymphoid proliferations that can mimic lymphoma * -IgG4-related disease* -Unicentric Castleman disease* -Idiopathic multicentric Castleman disease* -KSHV/HHV8-associated multicentric Castleman disease ( 4th Edでは, Multicentric Castleman disease *; Not previously included in WHO 4th Ed #br #br ***Precursor B-cell neoplasms [#oa5e5e55] ''B-cell lymphoblastic leukaemias/lymphomas'' >[ ]内はWHO 4th revised でのentity名です. 5th Edでは削除された項目もある. [Not previously included]は5thで新たに加えられたentity, [Same]は変更なしのentity. -B-lymphoblastic leukaemia/lymphoma, NOS [Same] -B-lymphoblastic leukaemia/lymphoma with ''high hyperdiploidy'' [B-lymphoblastic leukaemia/lymphoma with hyperdiploidy] -B-lymphoblastic leukaemia/lymphoma ''with hypodiploidy'' [Same] -B-lymphoblastic leukaemia/lymphoma &color(#d7003a){''with iAMP21''}; [Same] -B-lymphoblastic leukaemia/lymphoma &color(#d7003a){''with BCR::ABL1 fusion''}; [B-lymphoblastic leukaemia/lymphoma with t(9;22)(q34;q11.2); BCR-ABL1] -B-lymphoblastic leukaemia/lymphoma &color(#d7003a){''with BCR::ABL1-like features''}; [B-lymphoblastic leukaemia/lymphoma, BCR-ABL1-like] -B-lymphoblastic leukaemia/lymphoma &color(#d7003a){''with KMT2A rearrangement''}; [B-lymphoblastic leukaemia/lymphoma with t(v;11q23.3); KMT2A-rearranged] -B-lymphoblastic leukaemia/lymphoma &color(#d7003a){''with ETV6::RUNX1 fusion''}; [B-lymphoblastic leukaemia/lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1]] -B-lymphoblastic leukaemia/lymphoma &color(#d7003a){''with ETV6::RUNX1-like features''}; [Not previously included] -B-lymphoblastic leukaemia/lymphoma &color(#d7003a){''with TCF3::PBX1 fusion''}; [B-lymphoblastic leukaemia/lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1] -B-lymphoblastic leukaemia/lymphoma &color(#d7003a){''with IGH::IL3 fusion''}; [B-lymphoblastic leukaemia/lymphoma with t(5;14)(q31.1;q32.1); IGH/IL3] -B-lymphoblastic leukaemia/lymphoma &color(#d7003a){''with TCF3::HLF fusion''}; [Not previously included] -B-lymphoblastic leukaemia/lymphoma &color(#d7003a){''with other defined genetic abnormalities''}; [same] #br #br ***Mature B-cell neoplasms [#f40754a0] ''Pre-neoplastic and neoplastic small lymphocytic proliferations'' -Monoclonal B-cell lymphocytosis (Same) -Chronic lymphocytic leukaemia/small lymphocytic lymphoma (Same) - [B-cell prolymphocytic leukaemia]; Entity deleted ''Splenic B-cell lymphomas and leukaemias'' -Hairy cell leukaemia (Same) -Splenic marginal zone lymphoma (Same) -Splenic diffuse red pulp small B-cell lymphoma (Same) -Splenic B-cell lymphoma/leukaemia with prominent nucleoli [Not previously included (encompassing hairy cell leukaemia variant and some cases of B-cell prolymphocytic leukaemia)] #br ''Lymphoplasmacytic lymphoma'' -Lymphoplasmacytic lymphoma [same] ''Marginal zone lymphoma'' -Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue [same] -Primary cutaneous marginal zone lymphoma [Not previously included (originally included under “extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue”)] -Nodal marginal zone lymphoma [same] -Paediatric marginal zone lymphoma [same] #br ''Follicular lymphoma'' -In situ follicular B-cell neoplasm In situ follicular neoplasia -Follicular lymphoma [Same] -Paediatric-type follicular lymphoma [Same] -Duodenal-type follicular lymphoma [Same] ''Cutaneous follicle centre lymphoma'' -Primary cutaneous follicle centre lymphoma [Same] ''Mantle cell lymphoma'' -In situ mantle cell neoplasm In situ mantle cell neoplasia -Mantle cell lymphoma [Same] -Leukaemic non-nodal mantle cell lymphoma [Same] ''Transformations of indolent B-cell lymphomas'' -Transformations of indolent B-cell lymphomas [Not previously included] ''Large B-cell lymphomas'' -Diffuse large B-cell lymphoma, NOS [Same] -T-cell/histiocyte-rich large B-cell lymphoma [Same] -Diffuse large B-cell lymphoma/ high grade B-cell lymphoma with MYC and BCL2 rearrangements -High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements -ALK-positive large B-cell lymphoma [Same] -Large B-cell lymphoma with IRF4 rearrangement [Same] -High-grade B-cell lymphoma with 11q aberrations Burkitt-like lymphoma with 11q aberration -Lymphomatoid granulomatosis [Same] -EBV-positive diffuse large B-cell lymphoma EBV-positive diffuse large B-cell lymphoma, NOS -Diffuse large B-cell lymphoma associated with chronic inflammation [Same] -Fibrin-associated large B-cell lymphoma Not previously included [Previously considered a subtype of diffuse large B-cell lymphoma associated with chronic inflammation] -Fluid overload-associated large B-cell lymphoma Not previously included -Plasmablastic lymphoma [Same] -Primary large B-cell lymphoma of immune-privileged sites Not previously included, encompassing primary diffuse large B-cell lymphoma of the CNS in revised 4th edition [plus primary large B-cell lymphoma of the vitreoretina and primary large B-cell lymphoma of the testis] -Primary cutaneous diffuse large B-cell lymphoma, leg type [Same] -Intravascular large B-cell lymphoma [Same] -Primary mediastinal large B-cell lymphoma [Same] -Mediastinal grey zone lymphoma B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classic Hodgkin lymphoma -High-grade B-cell lymphoma, NOS [Same] ''Burkitt lymphoma'' -Burkitt lymphoma [Same] ''KSHV/HHV8-associated B-cell lymphoid proliferations and lymphomas'' -Primary effusion lymphoma [Same] -KSHV/HHV8-positive diffuse large B-cell lymphoma HHV8-positive diffuse large B-cell lymphoma, NOS -KSHV/HHV8-positive germinotropic lymphoproliferative disorder -HHV8-positive germinotropic lymphoproliferative disorder ''Lymphoid proliferations and lymphomas associated with immune deficiency and dysregulation'' -Hyperplasias arising in immune deficiency/dysregulation [Not previously included, encompassing non-destructive post-transplant lymphoproliferative disorders, among others] -Polymorphic lymphoproliferative disorders arising in immune deficiency/dysregulation [Not previously included, encompassing polymorphic posttransplant lymphoproliferative disorders, other iatrogenic immunodeficiency-associated lymphoproliferative disorders, among others] -EBV-positive mucocutaneous ulcer [Same] -Lymphomas arising in immune deficiency / dysregulation [Not previously included, encompassing monomorphic posttransplant lymphoproliferative disorders, classic Hodgkin lymphoma posttransplant lymphoproliferative disorders, lymphomas associated with HIV infection, among others] -Inborn error of immunity-associated lymphoid proliferations and lymphomas [Lymphoproliferative diseases associated with primary immune disorders] ***Hodgkin lymphoma [#be9edea1] -Classic Hodgkin lymphoma [Same] -Nodular lymphocyte predominant Hodgkin lymphoma [Same] #br ***Plasma cell neoplasms and other diseases with paraproteins [#w30117c1] -Monoclonal gammopathies -Cold agglutinin disease Not previously included IgM monoclonal gammopathy of undetermined significance [Same] -Non-IgM monoclonal gammopathy of undetermined significance [Same] -Monoclonal gammopathy of renal significance [Not previously included] #br ''Diseases with monoclonal immunoglobulin deposition'' -Immunoglobulin-related [AL] amyloidosis [Primary amyloidosis] -Monoclonal immunoglobulin deposition disease [Light chain and heavy chain deposition disease] ''Heavy chain diseases'' -Mu heavy chain disease [Same] -Gamma heavy chain disease [Same] -Alpha heavy chain disease [Same] ''Plasma cell neoplasms'' -Plasmacytoma [Same] -Plasma cell myeloma [Same] -Plasma cell neoplasms with associated paraneoplastic syndrome --POEMS syndrome --TEMPI syndrome --AESOP syndrome #br #br #aname(T-cell); *T-cell and NK ell proliferation/lymphoma [#fda57cd6] [ ]内はWHO 4th revised でのentity名です. 5th Edでは削除された項目もある. [Not previously included]は5thで新たに加えられたentity, [Same]は変更なしのentity. ***Tumour-like lesions with T-cell predominance [#l3d81534] -Kikuchi-Fujimoto disease [Not previously included] -Indolent T-lymphoblastic proliferation [Not previously included] -Autoimmune lymphoproliferative syndrome [Not previously included] ***Precursor T-cell neoplasms [#xbcc125c] ''T-lymphoblastic leukaemia/lymphoma'' -T-lymphoblastic leukaemia / lymphoma, NOS [T-lymphoblastic leukaemia/lymphoma] -Early T-precursor lymphoblastic leukaemia / lymphoma [Early T-cell precursor lymphoblastic leukaemia] -[Entity deleted] NK-lymphoblastic leukaemia/lymphoma ***Mature T-cell and NK-cell neoplasms [#kab314d1] ''Mature T-cell and NK-cell leukaemias'' -T-prolymphocytic leukaemia [Same] -T-large granular lymphocytic leukaemia [T-cell large granular lymphocytic leukaemia] -NK-large granular lymphocytic leukaemia [Chronic lymphoproliferative disorder of NK cells] -Adult T-cell leukaemia/lymphoma [Same] -Sezary syndrome [Same] -Aggressive NK-cell leukaemia [Same] #br ''Primary cutaneous T-cell lymphomas'' -Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder [Same] -Primary cutaneous acral CD8-positive lymphoproliferative disorder [Primary cutaneous acral CD8-positive T-cell lymphoma] -Mycosis fungoides [Same] -Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Lymphomatoid papulosis [Same] -Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Primary cutaneous anaplastic large cell lymphoma [Same] -Subcutaneous panniculitis-like T-cell lymphoma [Same] -Primary cutaneous gamma/delta T-cell lymphoma [Same] -Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma [Same] -Primary cutaneous peripheral T-cell lymphoma, NOS [Not previously included] #br ''Intestinal T-cell and NK-cell lymphoid proliferations and lymphomas'' -Indolent T-cell lymphoma of the gastrointestinal tract Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract -Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract [Not previously included] -Enteropathy-associated T-cell lymphoma [Same] -Monomorphic epitheliotropic intestinal T-cell lymphoma [Same] -Intestinal T-cell lymphoma, NOS [Same] #br ''Hepatosplenic T-cell lymphoma'' -Hepatosplenic T-cell lymphoma [Same] #br ''Anaplastic large cell lymphoma'' -ALK-positive anaplastic large cell lymphoma [Anaplastic large cell lymphoma, ALK-positive] -ALK-negative anaplastic large cell lymphoma [Anaplastic large cell lymphoma, ALK-negative] -Breast implant-associated anaplastic large cell lymphoma [Same] #br ''Nodal T-follicular helper [TFH] cell lymphoma'' -Nodal TFH cell lymphoma, angioimmunoblastic-type Angioimmunoblastic T-cell lymphoma -Nodal TFH cell lymphoma, follicular-type Follicular T-cell lymphoma -Nodal TFH cell lymphoma, NOS Nodal peripheral T-cell lymphoma with TFH phenotype ''Other peripheral T-cell lymphomas'' -Peripheral T-cell lymphoma, not otherwise specified [Same] ''EBV-positive NK/T-cell lymphomas'' -EBV-positive nodal T- and NK-cell lymphoma Not previously included -Extranodal NK/T-cell lymphoma Extranodal NK/T-cell lymphoma, nasal-type #br ''EBV-positive T- and NK-cell lymphoid proliferations and lymphomas of childhood'' -Severe mosquito bite allergy [Same] -Hydroa vacciniforme lymphoproliferative disorder [Hydroa vacciniforme-like lymphoproliferative disorder] -Systemic chronic active EBV disease [Chronic active EBV infection of T- and NK-cell type, systemic form] -Systemic EBV-positive T-cell lymphoma of childhood [Same] ***Mesenchymal dendritic cell neoplasms [#y9be3531] -Follicular dendritic cell sarcoma [Same] -EBV-positive inflammatory follicular dendritic cell sarcoma Inflammatory pseudotumour-like follicular/fibroblastic dendritic cell sarcoma -Fibroblastic reticular cell tumour [Same] -Myofibroblastic tumour -Intranodal palisaded myofibroblastoma [Not previously included] #br ''Spleen-specific vascular-stromal tumours'' -Splenic vascular-stromal tumours -Littoral cell angioma [Not previously included] -Splenic hamartoma [Not previously included] -Sclerosing angiomatoid nodular transformation of spleen [Not previously included]
