Undifferentiated small round cell tumors of the sinonasal tract
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開始行:
[[Wikipathologica-KDP]]
*Undifferentiated (small) round cell tumors of the Sinona...
#br
>''鼻腔副鼻腔発生の｢未分化な｣小円形細胞腫瘍''¬e{:Iezzo...
HE染色標本を十分に吟味することはもちろん重要なことである...
以下に該当する腫瘍を列挙する。（ブラウンの文字は症例ペー...
>
細胞は円形細胞のことが多いが%%%必ずしもsmallとは限らない%...
#br
>1. olfactory neuroblastoma
>2. sinonasal undifferentiated carcinoma
>3. small cell undifferentiated (neuroendocrine) carcinoma
>4. undifferentiated (lymhoepithelioma-like) carcinoma &n...
>5. [[sinonasal malignant melanoma]]
>6. malignant lymphoma
>7. pituitary adenoma
>8. Ewing sarcoma/ peripheral neuroectodermal tumor
>9. [[rhabdomyosarcoma>rhabdomyosarcoma-Iwata City Hospit...
>10. mesenchymal chondrosarcoma
>11. small cell osteosarcoma
>12. synovial sarcoma
>13. extranodal natural killer/ T-cell lymphoma, nasal type
>14. [[extramedullary plasmacytoma>Extramedullary plasmac...
>&color(red){15. [[NUT midline carcinoma arising in the n...
#br
#br
***extranodal natural killer/ T-cell lymphoma, nasal type...
>鼻, 副鼻腔領域より採取された組織が, ''壊死の強い炎症性肉...
臨床に対して, ｢壊死組織です｣と安易に返事をすると痛い目に...
>&color(red){''鼻・副鼻腔の壊死組織では extranodal natura...
#br
>''IWT case 64year-old female''
#gallery(left,nowrap,noadd){{
nosenecrotic01.jpg>HE loupe
nosenecrotic-HE_c.jpg>HE
nosenecrotic-CD56_b.jpg>CD56
nosenecrotic-EBV_b.jpg>EBER-ISH
}}
>左から鼻腔より採取された壊死組織断片。真菌の増殖がある。...
#br
''extranodal natural killer/ T-cell lymphoma, nasal type...
1.血管浸潤, 壊死型--->組織像図1. 血管に浸潤, 壊死を来す胡...
2.DLBCL型--->組織図2 大型異型性高度, centroblastic, immun...
3.小型低異型度型--->組織像図3 小型で低異型度のリンパ球が...
&color(red){診断はCD3+(細胞質＋, 表面-; FCMの抗体ではsCD3...
''ごくまれにEBER-ISHが陰性を示しEBVの証明ができない例があ...
***頭頸部のリンパ腫 [#z673fe49]
#ref(headandneck-lymphoma.jpg,around,left,80%)
#clear
**Expanding field of undifferentiated epithelial and neur...
up date¬e{:Adamane S and Weir J. A diagnostic approach...
Olfactory neuroblastoma/olfactory carcinoma/sinonasal tum...
Olfactory neuroblastoma (ONB)
Olfactory carcinoma (OC)
Sinonasal small cell neuroendocrine carcinoma (SNEC)
Sinonasal large cell neuroendocrine carcinoma
IDH2-mutated sinonasal carcinoma
Nonkeratinizing squamous cell carcinoma (NKSCC)
Sinonasal DEK::AFF2 carcinoma
NUT carcinoma (NUT-C)
SWI/SNF complex-deficient sinonasal carcinoma
SMARCB 1-deficient sinonasal carcinoma (SDSC)
SMARCA 4-deficient sinonasal carcinoma
SMARCA 4-deficient sinonasal teratocarcinosarcoma (TCS)
Sinonasal undifferentiated carcinoma (SNUC)
Adamantinoma-like Ewing sarcoma
PRACTICE POINTS
- An understanding of the expanded classification of undi...
- An appreciation of the appropriate immunohistochemistry...
- The appropriate use of next-generation sequencing to id...
- Wide range of differential diagnoses which include sarc...
-未分化上皮性腫瘍と神経上皮性腫瘍/神経内分泌腫瘍の拡大分...
-必要とされる適切な免疫組織化学の理解
-特定の変異を同定するための次世代シーケンサーの適切な使用
-肉腫、リンパ腫、黒色腫、分化型癌を含む幅広い鑑別診断
*[[Spindle cell mesenchymal tumours of the head and neck]...
Emerging and recently described entities characterised by...
終了行:
[[Wikipathologica-KDP]]
*Undifferentiated (small) round cell tumors of the Sinona...
#br
>''鼻腔副鼻腔発生の｢未分化な｣小円形細胞腫瘍''¬e{:Iezzo...
HE染色標本を十分に吟味することはもちろん重要なことである...
以下に該当する腫瘍を列挙する。（ブラウンの文字は症例ペー...
>
細胞は円形細胞のことが多いが%%%必ずしもsmallとは限らない%...
#br
>1. olfactory neuroblastoma
>2. sinonasal undifferentiated carcinoma
>3. small cell undifferentiated (neuroendocrine) carcinoma
>4. undifferentiated (lymhoepithelioma-like) carcinoma &n...
>5. [[sinonasal malignant melanoma]]
>6. malignant lymphoma
>7. pituitary adenoma
>8. Ewing sarcoma/ peripheral neuroectodermal tumor
>9. [[rhabdomyosarcoma>rhabdomyosarcoma-Iwata City Hospit...
>10. mesenchymal chondrosarcoma
>11. small cell osteosarcoma
>12. synovial sarcoma
>13. extranodal natural killer/ T-cell lymphoma, nasal type
>14. [[extramedullary plasmacytoma>Extramedullary plasmac...
>&color(red){15. [[NUT midline carcinoma arising in the n...
#br
#br
***extranodal natural killer/ T-cell lymphoma, nasal type...
>鼻, 副鼻腔領域より採取された組織が, ''壊死の強い炎症性肉...
臨床に対して, ｢壊死組織です｣と安易に返事をすると痛い目に...
>&color(red){''鼻・副鼻腔の壊死組織では extranodal natura...
#br
>''IWT case 64year-old female''
#gallery(left,nowrap,noadd){{
nosenecrotic01.jpg>HE loupe
nosenecrotic-HE_c.jpg>HE
nosenecrotic-CD56_b.jpg>CD56
nosenecrotic-EBV_b.jpg>EBER-ISH
}}
>左から鼻腔より採取された壊死組織断片。真菌の増殖がある。...
#br
''extranodal natural killer/ T-cell lymphoma, nasal type...
1.血管浸潤, 壊死型--->組織像図1. 血管に浸潤, 壊死を来す胡...
2.DLBCL型--->組織図2 大型異型性高度, centroblastic, immun...
3.小型低異型度型--->組織像図3 小型で低異型度のリンパ球が...
&color(red){診断はCD3+(細胞質＋, 表面-; FCMの抗体ではsCD3...
''ごくまれにEBER-ISHが陰性を示しEBVの証明ができない例があ...
***頭頸部のリンパ腫 [#z673fe49]
#ref(headandneck-lymphoma.jpg,around,left,80%)
#clear
**Expanding field of undifferentiated epithelial and neur...
up date¬e{:Adamane S and Weir J. A diagnostic approach...
Olfactory neuroblastoma/olfactory carcinoma/sinonasal tum...
Olfactory neuroblastoma (ONB)
Olfactory carcinoma (OC)
Sinonasal small cell neuroendocrine carcinoma (SNEC)
Sinonasal large cell neuroendocrine carcinoma
IDH2-mutated sinonasal carcinoma
Nonkeratinizing squamous cell carcinoma (NKSCC)
Sinonasal DEK::AFF2 carcinoma
NUT carcinoma (NUT-C)
SWI/SNF complex-deficient sinonasal carcinoma
SMARCB 1-deficient sinonasal carcinoma (SDSC)
SMARCA 4-deficient sinonasal carcinoma
SMARCA 4-deficient sinonasal teratocarcinosarcoma (TCS)
Sinonasal undifferentiated carcinoma (SNUC)
Adamantinoma-like Ewing sarcoma
PRACTICE POINTS
- An understanding of the expanded classification of undi...
- An appreciation of the appropriate immunohistochemistry...
- The appropriate use of next-generation sequencing to id...
- Wide range of differential diagnoses which include sarc...
-未分化上皮性腫瘍と神経上皮性腫瘍/神経内分泌腫瘍の拡大分...
-必要とされる適切な免疫組織化学の理解
-特定の変異を同定するための次世代シーケンサーの適切な使用
-肉腫、リンパ腫、黒色腫、分化型癌を含む幅広い鑑別診断
*[[Spindle cell mesenchymal tumours of the head and neck]...
Emerging and recently described entities characterised by...
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